Info on Poloxamer 407
Also known as: Poloxamer 188, Pluronic L-81, Poloxalene, POLOXAMER, Tergitol XH, Pluronic F68, Pluronic L44, Poloxamer 407, Pluronic F 38
Molecular Formula: C5H10O2
Molecular Weight: 102.1317
Reports of Adverse Effects:
It was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol. A team from the Centre for Ageing and the ANZAC Research Institute in Sydney found that when P407 was given to mice, it coated cells in the liver that control cholesterol levels, leading to a 10-fold increase in levels. The dose administered was 1g/kg by inter-peritoneal injection.
Uses of Poloxamer 407:
Most of the common uses of poloxamer 407 are related to its surfactant properties. For example, it is widely used in cosmetics for dissolving oily ingredients in water. It can also be found in multi-purpose contact lens cleaning solutions, where its purpose there is to help remove lipid films from the lens. It can also be found in some mouthwashes. There is a research ongoing for using poloxamer 407 for aligning severed blood vessels before gluing them surgically.
Molecular Formula: C5H10O2
Molecular Weight: 102.1317
Reports of Adverse Effects:
It was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol. A team from the Centre for Ageing and the ANZAC Research Institute in Sydney found that when P407 was given to mice, it coated cells in the liver that control cholesterol levels, leading to a 10-fold increase in levels. The dose administered was 1g/kg by inter-peritoneal injection.
Uses of Poloxamer 407:
Most of the common uses of poloxamer 407 are related to its surfactant properties. For example, it is widely used in cosmetics for dissolving oily ingredients in water. It can also be found in multi-purpose contact lens cleaning solutions, where its purpose there is to help remove lipid films from the lens. It can also be found in some mouthwashes. There is a research ongoing for using poloxamer 407 for aligning severed blood vessels before gluing them surgically.